WH0000817M2

Monoclonal Anti-CAMK2D antibody produced in mouse

clone 1A8, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-CAMKD, Anti-MGC44911, Anti-calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 1A8, monoclonal
• form: buffered aqueous solution
• species reactivity: mouse
• technique(s): indirect ELISA: suitable; indirect immunofluorescence: suitable; western blot: 1-5 μg/mL
• isotype: IgG2bλ
• GenBank accession no.: BC032784
• UniProt accession no.: Q6PHZ2
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CAMK2D(817)

Description

General description

The gene encoding calcium/calmodulin dependent protein kinase IIδ (CAMK2D) is localized on human chromosome 4q26. The encoded protein is a member of serine/threonine protein kinase family and the Ca²⁺/calmodulin-dependent protein kinase subfamily.

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: α, β, γ, and δ. The product of this gene is a δ chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns

Immunogen

CAMK2D (AAH32784, 301 a.a. ~ 410 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPI

Biochem/physiol Actions

As a subunit of the calcium/calmodulin dependent protein kinase II complex, calcium/calmodulin dependent protein kinase II complex δ (CAMK2D) modulates the functions of ion channels and Ca²⁺ handling proteins. It also regulates the phosphorylation and acetylation of histones. CAMK2D has been shown to be overexpressed in the myocardium of diabetic patients.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

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Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)