V1880

[deamino-Pen¹, O-Me-Tyr², Arg⁸]-Vasopressin

≥97% (HPLC)

• Empirical Formula (Hill Notation): C₄₉H₇₀N₁₄O₁₂S₂
• CAS Number: 67269-08-3
• Molecular Weight: 1111.30
• NACRES: NA.32
• PubChem Substance ID: 24900721
• UNSPSC Code: 51111800
• MDL number: MFCD00076745
• Form: powder
• Assay: ≥97% (HPLC)

Properties

• sterility: non-sterile
• assay: ≥97% (HPLC)
• form: powder
• solubility: water: 0.5 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: COc1ccc(CC2NC(=O)CC(C)(C)SSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc3ccccc3)NC2=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O)cc1
• InChI: 1S/C49H70N14O12S2/c1-49(2)24-40(67)57-32(22-28-13-15-29(75-3)16-14-28)43(70)60-33(21-27-9-5-4-6-10-27)44(71)58-31(17-18-37(50)64)42(69)61-34(23-38(51)65)45(72)62-35(26-76-77-49)47(74)63-20-8-12-36(63)46(73)59-30(11-7-19-55-48(53)54)41(68)56-25-39(52)66/h4-6,9-10,13-16,30-36H,7-8,11-12,17-26H2,1-3H3,(H2,50,64)(H2,51,65)(H2,52,66)(H,56,68)(H,57,67)(H,58,71)(H,59,73)(H,60,70)(H,61,69)(H,62,72)(H4,53,54,55)
• InChI key: HNOGCDKPALYUIG-UHFFFAOYSA-N
• Gene Information: human ... AVPI1(60370) ; mouse ... AVPI1(69534) ; rat ... AVPI1(171386), LOC689723(689723)

Description

Application

[Deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin was used to inhibit the V1 receptor, and study the role of arginine vasopressin receptors V1 and V2 on brain damage, brain edema formation and functional outcome after transient focal cerebral ischemia.

Biochem/physiol Actions

[Deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin is a V1 antagonist that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It also stimulates three acid-base transporters and hence increases the capability of the cell to regulate pHi.

Preparation Note

[deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin dissolves in water at 0.5 mg/ml to yield a clear, colorless solution.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H332
• pcodes: P261 - P271 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Inhalation
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves