T7075
TIPP-Ψ
≥98% (HPLC), solid
Synonym(s):
H-Tyr-Tic(CH2NH)-Phe-Phe-OH
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About This Item
Empirical Formula (Hill Notation):
C37H40N4O5
CAS Number:
Molecular Weight:
620.74
MDL number:
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
solid
mol wt
(mass spec confirms mol. wt.)
color
white
solubility
DMSO: soluble
storage temp.
2-8°C
SMILES string
N[C@@H](Cc1ccc(O)cc1)C(=O)N2Cc3ccccc3C[C@H]2CN[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc5ccccc5)C(O)=O
Application
TIPP-Ψ has been used as a positive control during the screening for delta-opioid receptor (DOR) modulators.
Biochem/physiol Actions
Selective δ-opioid receptor antagonist.
Preparation Note
TIPP-Ψ is soluble in DMSO.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ting Zhu et al.
Acta pharmacologica Sinica, 29(4), 507-516 (2008-03-25)
To develop a universal high-throughput screening assay based on Galpha15/16- mediated calcium mobilization for the identification of novel modulators of Gprotein- coupled receptors (GPCR). In the present study, CHO-K1 or HEK293 cells were co-transfected with plasmids encoding promiscuous G-protein Galpha15/16
N A Martin et al.
The Journal of pharmacology and experimental therapeutics, 298(1), 240-248 (2001-06-16)
A new class of highly selective delta-opioid receptor antagonists has been recently developed, termed the TIP(P) peptides. Two prototypical compounds in this class are TIPP (H-Tyr-Tic-Phe-Phe-OH) and a derivative, TIPP-psi (H-Tyr-Tic[CH2NH]-Phe-Phe-OH). Surprisingly, both TIPP and TIPP-psi demonstrated inhibition of adenylyl
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