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T4192

Sigma-Aldrich

Tyrphostin SU 1498

≥98%

Synonym(s):

(E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide

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About This Item

Empirical Formula (Hill Notation):
C25H30N2O2
CAS Number:
168835-82-3
Molecular Weight:
390.52
MDL number:
MFCD03453026
UNSPSC Code:
12352200
PubChem Substance ID:
24900199

assay

≥98%

form

solid

potency

700 nM IC50

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

CC(C)c1cc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O

InChI

1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+

InChI key

JANPYFTYAGTSIN-FYJGNVAPSA-N

Application

Tyrphostin SU 1498 has been used as a VEGF inhibitor in mice1.

Biochem/physiol Actions

Potent and selective inhibitor of the VEGF receptor kinase, Flk-1. Very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase.

Preparation Note

Tyrphostin SU 1498 is soluble in DMSO.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Xiaorui Shi
The American journal of pathology, 174(5), 1692-1704 (2009-04-08)
This study explored the effect of acoustic trauma on cochlear pericytes. Transmission electron microscopy revealed that pericytes on capillaries of the stria vascularis were closely associated with the endothelium in both control guinea pigs and mice. Pericyte foot processes were

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