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T3932

Sigma-Aldrich

Tyrphostin AG 1295

≥98%

Synonym(s):

6,7-Dimethyl-2-phenylquinoxaline

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About This Item

Empirical Formula (Hill Notation):
C16H14N2
CAS Number:
71897-07-9
Molecular Weight:
234.30
MDL number:
MFCD00270912
UNSPSC Code:
12352200
PubChem Substance ID:
24900180

assay

≥98%

solubility

0.1 M HCl: soluble <1 mg/mL
ethanol: soluble 10 mg/mL
methylene chloride: soluble 10 mg/mL
0.1 M NaOH: insoluble
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble

storage temp.

−20°C

SMILES string

Cc1cc2ncc(nc2cc1C)-c3ccccc3

Gene Information

human ... EGFR(1956) , FLT3(2322) , PDGFRB(5159) , SRC(6714)
mouse ... Pdgfrb(18596)

Application

Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines2. Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells3.
Tyrphostin AG 1295 is soluble in methylene chloride at 10 mg/ml, in ethanol at 10 mg/ml and in 0.1 N HCl at less than 1 mg/ml. It is however, insoluble in water, 0.1 N sodium hydroxide, and 2-hydroxypropyl-β-cyclodextrin.

Biochem/physiol Actions

Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.
Studies in mouse osteoblastic MC3T3-E1 cells have reported that AG 1295 can enhance matrix mineralization and osteoblast differentiation by inhibiting PDGFR-β signaling4.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
085K1743
102K0743
084K1244
083K1068
078H1328

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Ivo A Pestana et al.
Journal of cellular biochemistry, 96(5), 986-995 (2005-09-09)
Cigarette smoking is implicated in the formation of occlusive vascular diseases. Nicotine's role in this process is incompletely understood. Nicotine's effect on human aortic vascular smooth muscle cells (HaVSMC) and the role of the nicotinic receptor (nAChR), platelet-derived growth factor
M Kovalenko et al.
Cancer research, 54(23), 6106-6114 (1994-12-01)
A novel class of tyrosine kinase blockers represented by the tyrphostins AG1295 and AG1296 is described. These compounds inhibit selectively the platelet-derived growth factor (PDGF) receptor kinase and the PDGF-dependent DNA synthesis in Swiss 3T3 cells and in porcine aorta
Y Y Zhang et al.
Bioscience trends, 6(3), 130-135 (2012-08-15)
Previous studies have conflicting views on the effect of platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling on osteogenesis. The current study investigated the effect of PDGF receptor-beta (PDGFR-β) inhibition by AG-1295 on the osteogenic differentiation of the mouse pre-osteoblastic cell
Lars Palmqvist et al.
Blood, 108(3), 1030-1036 (2006-07-25)
In leukemogenesis, several genetic changes conferring a proliferative and/or survival advantage to hematopoietic progenitor cells in addition to a block in differentiation are required. Here, we demonstrate that overexpression of the wild-type (wt) Flt3 receptor tyrosine kinase collaborates with NUP98-HOX
Junichi Kasuya et al.
Journal of tissue engineering and regenerative medicine, 9(3), 247-256 (2012-10-23)
In liver sinusoids, hepatic stellate cells (HSCs) locate the outer surface of microvessels to form a functional unit with endothelia and hepatocytes. To reconstruct functional liver tissue in vitro, formation of the HSC-incorporated sinusoidal structure is essential. We previously demonstrated

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