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T2803

7-Ethoxy-4-(trifluoromethyl)coumarin

≥98% (TLC), powder

Synonym(s):

Ethyl 4-(trifluoromethyl)umbelliferyl ether

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5 MG

$464.00

$464.00

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About This Item

Empirical Formula (Hill Notation):
C12H9F3O3
CAS Number:
115453-82-2
Molecular Weight:
258.19
NACRES:
NA.32
PubChem Substance ID:
24900082
UNSPSC Code:
12352204
MDL number:
MFCD00467588
Beilstein/REAXYS Number:
8555209

Key Documents

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Product Name

7-Ethoxy-4-(trifluoromethyl)coumarin, ≥98% (TLC)

InChI key

OLHOIERZAZMHGK-UHFFFAOYSA-N

SMILES string

CCOc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C12H9F3O3/c1-2-17-7-3-4-8-9(12(13,14)15)6-11(16)18-10(8)5-7/h3-6H,2H2,1H3

assay

≥98% (TLC)

form

powder

solubility

chloroform: 100 mg/mL, clear, colorless (Soluble in chloroform, methanol, and DMSO.)

fluorescence

λex 333 nm; λem 415 nm in methanol

storage temp.

−20°C

Quality Level

100

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1 of 4

This Item
T3165N0252SML2821
7-Ethoxy-4-(trifluoromethyl)coumarin ≥98% (TLC)

Sigma-Aldrich

T2803

7-Ethoxy-4-(trifluoromethyl)coumarin

7-Methoxy-4-(trifluoromethyl)coumarin ≥99% (TLC)

Sigma-Aldrich

T3165

7-Methoxy-4-(trifluoromethyl)coumarin

4-Nitrophenyl decanoate lipase substrate

Sigma-Aldrich

N0252

4-Nitrophenyl decanoate

DiFMUP ≥98% (HPLC)

Sigma-Aldrich

SML2821

DiFMUP

assay

≥98% (TLC)

assay

≥99% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

solubility

chloroform: 100 mg/mL, clear, colorless (Soluble in chloroform, methanol, and DMSO.)

solubility

acetone: 50 mg/mL, clear, colorless to faintly yellow

solubility

chloroform: soluble 100 mg/mL, colorless to faintly yellow

solubility

DMSO: 2 mg/mL, clear

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

100

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

room temp

fluorescence

λex 333 nm; λem 415 nm in methanol

fluorescence

λex 333 nm; λem 416 nm in methanol

fluorescence

-

fluorescence

-

Features and Benefits

7-Ethoxy-4-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P-450 catalyzed O-de-ethylation.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK7698
BCCH9325
BCCF9853
BCCF2735
BCCD6331

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J G DeLuca et al.
Biochemical pharmacology, 37(9), 1731-1739 (1988-05-01)
The microsomal O-deethylation of a novel coumarin analog, 7-ethoxy-4-trifluoromethylcoumarin (EFC), to a fluorescent product was characterized. Results indicate that this analog provides a rapid, convenient and highly sensitive means to assay cytochrome P-450-mediated metabolism. Like microsomal 7-ethoxycoumarin (7-EC) O-deethylation, EFC
Shih-Feng Lan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(4), 1314-1323 (2010-02-23)
In this study, we have evaluated the use of ultra-sterile alginate hydrogels encapsulated with HepG2 liver cells for applications in high throughput drug screening. We have studied the cellular viability and metabolic capacity of the encapsulated cells in two different
Chitra Sridar et al.
The Journal of pharmacology and experimental therapeutics, 301(3), 945-952 (2002-05-23)
Tamoxifen is primarily used in the treatment of breast cancer. It has been approved as a chemopreventive agent for individuals at high risk for this disease. Tamoxifen is metabolized to a number of different products by cytochrome P450 enzymes. The
Xilin Li et al.
Toxicological sciences : an official journal of the Society of Toxicology, 175(2), 251-265 (2020-03-12)
Metabolism plays a key role in chemical genotoxicity; however, most mammalian cells used for in vitro genotoxicity testing lack effective metabolizing enzymes. We recently developed a battery of TK6-derived cell lines that individually overexpress 1 of 8 cytochrome P450s (CYP1A1
Emily E Scott et al.
Chemical research in toxicology, 15(11), 1407-1413 (2002-11-20)
Until recently, all known structures of bacterial cytochromes P450 suggested that substrate access to the buried active site occurred via the F-G region, a surface loop distal to the heme cavity. However, the structure of P450 51 indicates a large
View All Related Papers

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