SRP6278

TDRD12-BD2 (908-999) his tag human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Synonym(s): ECAT8
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥98% (SDS-PAGE)
• form: liquid
• mol wt: 13 kDa
• packaging: pkg of 1 mg; pkg of 100 μg; pkg of 20 μg
• concentration: 2 mg/mL
• UniProt accession no.: Q587J7
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... TDRD12(91646)

Description

General description

Tudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. Tudor domain proteins act as an oncogene and play a very important role in HCC and colon cancer. TDRD is also involved in RISC complex and interacts with AEG-1 oncogene. The tudor domain can bind to methylated arginine protein and promote tumor angiogenesis in human hepatocellular carcinoma, etc. The recombinant protein includes TDRD12 (domain 908-999aa) with N-terminal His-tag.

Physical form

rh-TDRD12-BD2 is supplied as a solution in PBS Buffer containing 10% glycerol.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable