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SRP6124

Sigma-Aldrich

SORD human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):

L-iditol 2-dehydrogenase, Sorbitol dehydrogenase

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About This Item

CAS Number:
9028-21-1
UNSPSC Code:
12352202

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

liquid

mol wt

40.4 kDa (377 aa, 1-357 aa + NT His Tag)

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles

NCBI accession no.

Q00796

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... SORD(6652)

General description

SORD, also known as L-iditol 2-dehydrogenase or SORD1, is a 357 amino acid member of the zinc containing alcohol dehydrogenase family. It is widely expressed with highest expression in kidney and in the lens of the eye. SORD enzymatically catalyzes the zinc-dependent interconversion of polyols, such as sorbitol and xylitol, to their respective ketoses.

Physical form

0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 5 mM DTT and 20% glycerol.

Preparation Note

Centrifuge the vial prior to opening.

Other Notes

MGSSHHHHHH SSGLVPRGSH MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVKHLKPGD RVAIEPGAPR ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPIGMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKPEVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TVPLLHAAIR EVDIKGVFRY CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPSDQNP

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Miguel A Lanaspa et al.
Nature communications, 4, 2434-2434 (2013-09-12)
Carbohydrates with high glycaemic index are proposed to promote the development of obesity, insulin resistance and fatty liver, but the mechanism by which this occurs remains unknown. High serum glucose concentrations are known to induce the polyol pathway and increase

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