Skip to Content
MilliporeSigma
All Photos(2)

Documents

SML3838

Sigma-Aldrich

TP003

≥98% (HPLC)

Synonym(s):

2′,4-Difluoro-5′-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]pyridin-3-yl]-[1,1′-biphenyl]-2-carbonitrile, 4,2’-Difluoro-5’-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]pyridine-3-yl]biphenyl-2-carbonitrile, TP-003

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C23H16F3N3O
CAS Number:
628690-75-5
Molecular Weight:
407.39
MDL number:
MFCD13152400
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

TP003 is a potent and subtype selective agonist at α3 GABAA receptors that exhibits an anxiolytic-like effect in both rodent and non-human primate behavioral models of anxiety. Also it appears that TP003 have anxiolytic properties but lacks ataxic, hyperphagic, and pronounced sedative effects characteristic of classical benzodiazepines in monkeys. TP003 is consider as α3-over-α1 selective positive allosteric modulator (PAM) at GABBAAR.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors
Biochemical Pharmacology, 158, 339-358 (2018)
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
The Journal of Neuroscience, 25(46), 10682-10688 (2005)
Contribution of GABA(A) receptors containing ?3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys
Psychopharmacology, 215(2), 311-319 (2011)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service