SML3767

AA-263

≥98% (HPLC)

• Synonym(s): 2-Hydroxybenzaldehyde 2-(4-nitrophenyl)hydrazone, NSC 101540, Salicylaldehyde 4-nitrophenylhydrazone, o-Hydroxybenzaldehyde p-nitrophenylhydrazone
• Empirical Formula (Hill Notation): C₁₃H₁₁N₃O₃
• CAS Number: 3155-24-6
• Molecular Weight: 257.24
• MDL number: MFCD00425292
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , Faint orange to Red
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [N+](=O)([O-])c1ccc(cc1)N\N=C\c2c(cccc2)O
• InChI: 1S/C13H11N3O3/c17-13-4-2-1-3-10(13)9-14-15-11-5-7-12(8-6-11)16(18)19/h1-9,15,17H/b14-9+
• InChI key: VQIJGQPVYQKSSH-NTEUORMPSA-N

Description

Biochem/physiol Actions

AA-263 is a cell penetrant, potent and selective ATF6 activator that corrects the trafficking, conformation, secretion, and function of AAT-Z. AA-263 increases AAT neutrophil elastase (NE) inhibitory activity, while reducing polymer accumulation for the majority of AATD (alpha-1 antitrypsin (AAT) causes AAT deficiency) variants.

Cell penetrant, potent and selective ATF6 activator that corrects the trafficking, conformation, secretion, and function of AAT-Z

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable