SML3492
Chromenone 1
≥98% (HPLC)
Synonym(s):
2-(1H-1,2,4-Triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]-4H-1-benzopyran-4-one
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About This Item
Empirical Formula (Hill Notation):
C18H10F3N3O2
CAS Number:
Molecular Weight:
357.29
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1C(C2=CC=C(C=C2)C(F)(F)F)=C(OC3=CC=CC=C13)N4N=CN=C4
Biochem/physiol Actions
Chromenone 1 is a bone morphogenetic protein (BMP) signaling potentiator that exerts its effect via negative TGFβ feedback loops, independent of direct kinase inhibition. Chromenone 1 prevents cardiogenesis induction by 0.5 μM BMP inhibitor DMH1 (IC50 = 200 nM; mESC-Myh6-GFP) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts (ALP activity induction EC50 = 340 nM; E100% and Emax = induction by 7.5 and 50 ng/mL BMP-4, respectively).
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators
Journal of Medicinal Chemistry, 65 (2022)
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