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Key Documents

SML3062

Sigma-Aldrich

BSJ-04-122-R

≥98% (HPLC)

Synonym(s):

N-(2-((5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)phenyl)propionamide

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$92.70
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5 MG
$92.70
25 MG
$332.00

About This Item

Empirical Formula (Hill Notation):
C15H14ClN5O
CAS Number:
Molecular Weight:
315.76
UNSPSC Code:
12352200
NACRES:
NA.77

$92.70

List Price$103.00Save 10%

In StockDetails


Request a Bulk Order

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CNC2=NC=NC(NC3=CC=CC=C3NC(CC)=O)=C21

InChI

1S/C15H14ClN5O/c1-2-12(22)20-10-5-3-4-6-11(10)21-15-13-9(16)7-17-14(13)18-8-19-15/h3-8H,2H2,1H3,(H,20,22)(H2,17,18,19,21)

InChI key

XWBFUHLMYSMDTN-UHFFFAOYSA-N

Biochem/physiol Actions

BSJ-04-122-R is a reversible control for a potent and selective covalent inhibitor of MKK4 and MKK7 BSJ-04-122. BSJ-04-122-R des not inhibit JNK phosphorylation.
reversible control for a potent and selective covalent inhibitor of MKK4 and MKK7 BSJ-04-122

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Jie Jiang et al.
Cell chemical biology, 27(12), 1553-1560 (2020-09-12)
MKK4/7 are kinases that phosphorylate JNKs and regulate the MAPK signaling pathway. Their overexpression has been associated with tumorigenesis and aggressiveness in cancers such as breast, prostate, non-small cell lung, and pediatric leukemia, making them a potential target for inhibitor

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