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SML2751

Sigma-Aldrich

UCSF7447

≥98% (HPLC)

Synonym(s):

2-Bromo-4-chloro-N-[3-(1H-1,2,4-triazol-5-yl)phenyl]-benzenemethanamine, ZINC555417447

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5 MG
$78.18
25 MG
$268.00

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5 MG
$78.18
25 MG
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About This Item

Empirical Formula (Hill Notation):
C15H12BrClN4
CAS Number:
2305480-97-9
Molecular Weight:
363.64
UNSPSC Code:
12352200
NACRES:
NA.77

$78.18

List Price$82.30Save 5%

In StockDetails

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Brc1c(ccc(c1)Cl)CNc2cc(ccc2)c3[nH]ncn3

InChI

1S/C15H12BrClN4/c16-14-7-12(17)5-4-11(14)8-18-13-3-1-2-10(6-13)15-19-9-20-21-15/h1-7,9,18H,8H2,(H,19,20,21)

InChI key

QPTCYEYTAWEZNT-UHFFFAOYSA-N

Biochem/physiol Actions

UCSF7447 (ZINC555417447) brain permeable, potent and selective inverse agonist of both human and mouse melatonin MT1 receptor, which decelerates re-entrainment in mouse model of east-bound jetlag. Unexpectedly UCSF7447 advances the phase of the mouse circadian clock when administer at dusk.
brain permeable, potent and selective inverse agonist of both human and mouse melatonin MT1 receptor

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000110977
0000110808
0000105551

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Reed M Stein et al.
Nature, 579(7800), 609-614 (2020-02-11)
The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian release of melatonin at night from the pineal gland activates melatonin receptors in the suprachiasmatic nucleus of the hypothalamus

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