SML2500

Senicapoc

≥98% (HPLC)

• Synonym(s): 4-fluoro-α-(4-fluorophenyl)-α-phenyl-Benzeneacetamide, ICA 17043
• Empirical Formula (Hill Notation): C₂₀H₁₅F₂NO
• CAS Number: 289656-45-7
• Molecular Weight: 323.34
• MDL number: MFCD09027349
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(N)C(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3
• InChI: 1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
• InChI key: SCTZUZTYRMOMKT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

KCa3.1 channel blocker

Senicapoc (ICA-17043) is an inhibitor of the calcium-activated K⁺ channel KCa3.1, also known as the Gardos channel, which plays a role in K⁺ loss and dehydration of sickled red blood cells. Senicapoc blocks calcium-induced rubidium flux in human RBCs with and IC50 of 11 nM and prevents RBC dehydration in a transgenic mouse sickle cell disease model. It has been investigated for a number of possible uses, which include antimalarial activity, idiopathic pulmonary fibrosis, glioblastoma, lung cancer, non-alcoholic liver disease, hereditary xerocytosis, suppression of microglial activation in stroke, and immune system disorders.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable