SML1966
SK609 hydrochloride
≥98% (HPLC)
Synonym(s):
4-(2-Chlorophenyl)butan-2-amine hydrochloride, ES609, SK609•HCl
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About This Item
Empirical Formula (Hill Notation):
C10H14ClN · HCl
CAS Number:
Molecular Weight:
220.14
UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
under inert gas
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
SK609 (ES609) is a Dopamine D3 receptor (D3R) selective agonist with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation. SK609 has been shown to reverse akinesia and reduce L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson′s desease. It does not induce desensitization of D3R.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Sherise L Simms et al.
Neuropharmacology, 100, 106-115 (2015-04-22)
Synthetic dopaminergic agents have found utility in treating neurological and neuropsychiatric disorders since the beginning of 19th century. The discovery of Levodopa (l-dopa) to effectively treat motor symptoms of Parkinson's disease (PD) revolutionized the therapy and remains a gold standard
Wei Xu et al.
ACS chemical neuroscience, 8(3), 486-500 (2016-11-02)
Dopamine receptors play an integral role in controlling brain physiology. Importantly, subtype selective agonists and antagonists of dopamine receptors with biased signaling properties have been successful in treating psychiatric disorders with a low incidence of side effects. To this end
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