SML1400

AEE788

≥98% (HPLC)

• Synonym(s): 6-{4-[(4-Ethyl-1-piperazinyl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-1H-pyrrolo[2,3-d]pyrimidin-4-amine, CID 10297043, NVP-AEE 788, [6-[4-[(4-Ethylpiperazin-1-yl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-((R)-1-phenylethyl)amine
• Empirical Formula (Hill Notation): C₂₇H₃₂N₆
• CAS Number: 497839-62-0
• Molecular Weight: 440.58
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825848
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: C[C@H](C1=CC=CC=C1)NC2=C3C(NC(C4=CC=C(CN5CCN(CC)CC5)C=C4)=C3)=NC=N2
• InChI: 1S/C27H32N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-17-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,17,19-20H,3,13-16,18H2,1-2H3,(H2,28,29,30,31)/t20-/m1/s1
• InChI key: OONFNUWBHFSNBT-HXUWFJFHSA-N
• Gene Information: human ... EGFR(1956) , ERBB2(2064) , FLT1(2321) , KDR(3791)

Description

Biochem/physiol Actions

AEE788 is an orally available and potent dual family of human EGFR and VEGFR receptor tyrosine kinase inhibitor that exhibits potent antitumor and antiangiogenic activity.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable