SML1290

PA-824

≥98% (HPLC)

• Synonym(s): (6S)- 6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-Imidazo[2,1-b][1,3]oxazine, (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, (S)-PA 824, PA 824, Pretomanid
• Empirical Formula (Hill Notation): C₁₄H₁₂F₃N₃O₅
• CAS Number: 187235-37-6
• Molecular Weight: 359.26
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -40 to -48°, c = 1 in methanol
• color: white to brown
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: −20°C
• InChI: 1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
• InChI key: ZLHZLMOSPGACSZ-NSHDSACASA-N

Description

Biochem/physiol Actions

PA-824 is a pro-drug that has an effect on both replicating and non-replicating Mycobacterium tuberculosis. It is activated by deazaflavin (cofactor F420)-dependent nitroreducase.

PA-824 is an anti-tuberculosis drug that exhibits multiple mechanism of action, including both cell wall inhibition and respiratory poisoning.

PA-824 is an anti-tuberculosis drug.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable