SML0389

PF-514273

≥98% (HPLC)

• Synonym(s): 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
• Empirical Formula (Hill Notation): C₂₁H₁₇Cl₂F₂N₃O₂
• CAS Number: 851728-60-4
• Molecular Weight: 452.28
• MDL number: MFCD12032112
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825387
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >5 mg/mL (warmed)
• storage temp.: −20°C
• SMILES string: CC(F)(F)CN1CCOc2c(nn(-c3ccccc3Cl)c2-c4ccc(Cl)cc4)C1=O
• InChI: 1S/C21H17Cl2F2N3O2/c1-21(24,25)12-27-10-11-30-19-17(20(27)29)26-28(16-5-3-2-4-15(16)23)18(19)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3
• InChI key: FJMQJSUOOGOWBD-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PF-514273 is a highly selective CB1 antagonist. The Ki for binding to CB1 and CB2 receptors is 1 nM and 10 mM, respectively. PF-514273 inhibits food intake and weight gain in rodents.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable