SML0346

Alosetron hydrochloride

≥98% (HPLC)

• Synonym(s): 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride
• Empirical Formula (Hill Notation): C₁₇H₁₈N₄O·HCl
• CAS Number: 122852-69-1
• Molecular Weight: 330.81
• NACRES: NA.77
• PubChem Substance ID: 329825350
• UNSPSC Code: 12352200
• MDL number: MFCD09028027
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: ≥5 mg/mL at warmed
• storage temp.: 2-8°C
• SMILES string: CN1C2=C(C=CC=C2)C3=C1CCN(CC4=C(C)N=CN4)C3=O.Cl
• InChI: 1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H
• InChI key: FNYQZOVOVDSGJH-UHFFFAOYSA-N
• Gene Information: human ... HTR3A(3359)

Description

Biochem/physiol Actions

Alosetron is a potent and highly selective antagonist of serotonin 5-HT3 receptors, nonselective cation channels found predominantly in the enteric nervous system of the gastrointestinal tract. These receptors are involved in the regulation of visceral pain, colonic transit and GI secretions that can contribute to the pathophysiology of irritable bowel syndrome (IBS). Alosetron is used clinically for treatment of women with severe diarrhea-predominant IBS.

Alosetron is a potent and highly selective antagonist.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301,H319,H412
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• Precautionary Statements: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313