SAB5701799

Anti-Phospho-SHP1-Y564 antibody produced in rabbit

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody product type: primary antibodies
• clone: polyclonal
• form: liquid
• species reactivity: mouse, human
• concentration: 1.28 mg/mL
• technique(s): immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• UniProt accession no.: P29350
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr564)
• Gene Information: human ... PTPN6(5777)

Description

General description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Immunogen

A synthetic phosphorylated peptide around Y564 of human PTPN6 (NP_002822.2).

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable