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SAB5200101

Sigma-Aldrich

Anti-BSN antibody produced in rabbit

1 mg/mL, affinity isolated antibody

Synonym(s):

Anti- Neuronal double zine finger protein, Anti-BSN, Anti-Bassoon, Anti-ZNF231

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 420 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_003449.2

UniProt accession no.

Q9UPA5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BSN(8927)

General description

Bassoon presynaptic cytomatrix protein (BSN) is a 420kDa protein which is expressed in the neuronal synapses. The gene encoding it is located on human chromosome 3p21. The gene ID of the protein is 8927.

Specificity

Detects ~420 kDa, corresponding to the molecular mass of Bassoon. Multiple isoforms can be detected.

Immunogen

NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein

Biochem/physiol Actions

Bassoon presynaptic cytomatrix protein (BSN) acts as a scaffold protein and mediates release of neurotransmitters. It is also a part of trafficking and helps in delivery of proteins across the synapse.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS, pH 7..4, 50% glycerol, 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Pricing

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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C Winter et al.
Genomics, 57(3), 389-397 (1999-05-18)
Bassoon is a novel 420-kDa protein recently identified as a component of the cytoskeleton at presynaptic neurotransmitter release sites. Analysis of the rat and mouse sequences revealed a polyglutamine stretch in the C-terminal part of the protein. Since it is
Stefan Hallermann et al.
Neuron, 68(4), 710-723 (2010-11-26)
Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze
Nature, 447(7145), 661-678 (2007-06-08)
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the
Christopher Patzke et al.
Cell, 179(2), 498-513 (2019-10-05)
Neuromodulators bind to pre- and postsynaptic G protein-coupled receptors (GPCRs), are able to quickly change intracellular cyclic AMP (cAMP) and Ca2+ levels, and are thought to play important roles in neuropsychiatric and neurodegenerative diseases. Here, we discovered in human neurons

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