SAB4504621
Anti-phospho-MER/SKY (pTyr749/681) antibody produced in rabbit
affinity isolated antibody
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100 μG
$365.40
$365.40
List Price$522.00Save 30%Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
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100 μG
$365.40
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
$365.40
List Price$522.00Save 30%Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 110 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
UniProt accession no.
shipped in
wet ice
Storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr749/pTyr681)
Gene Information
human ... MERTK(10461) , TYRO3(7301)
General description
Tyro3 (TYRO3 protein tyrosine kinase) is an 890 amino acid protein that belongs to the TAM (Tyro3, Axl and Mer) receptor family. Tyro3 is mapped to human chromosome 15q15. It is highly expressed in the nervous system like the neocortex, hippocampus and cerebellum. It is also present in monocytes, macrophages, platelets, dendritic cells and NK cells, breast, ovary, testis, lung, kidney, retinal pigment epithelium and osteoclasts.
Immunogen
The antiserum was produced against synthesized peptide derived from human MER/SKY around the phosphorylation site of Tyr749/681.
Immunogen Range: 716-765
Immunogen Range: 716-765
Biochem/physiol Actions
Tyro3 (TYRO3 protein tyrosine kinase) serves as a therapeutic target in breast cancer. This protein is involved in spermatogenesis, immunoregulation, and phagocytosis. It controls disseminated prostate cancer cellular dormancy. TYRO3 helps in the survival and transport of of gonadotropin-releasing hormone (GnRH) neurons within the forebrain. Mutation in TYRO3 result in retinitis pigmentosa.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Mer tyrosine kinase regulates disseminated prostate cancer cellular dormancy.
Cackowski FC, et al.
Journal of Cellular Biochemistry, 118(4), 891-902 (2017)
Nour Al Kafri et al.
Biochemistry and biophysics reports, 30, 101263-101263 (2022-05-07)
The homologous proteins Gas6 and protein S (ProS1) are both natural ligands for the TAM (Tyro3, Axl, MerTK) receptor tyrosine kinases. ProS1 selectively activates Tyro3; however, the precise molecular interface of the ProS1-Tyro3 contact has not been characterised. We used
Ligand Recognition and Homophilic Interactions in Tyro3 STRUCTURAL INSIGHTS INTO THE Axl/Tyro3 RECEPTOR TYROSINE KINASE FAMILY.
Heiring C, et al.
The Journal of Biological Chemistry, 279(8), 6952-6958 (2004)
TYRO3 as a potential therapeutic target in breast cancer.
Ekyalongo RC, et al.
Anticancer Research, 34(7), 3337-3345 (2014)
A novel MERTK mutation causing retinitis pigmentosa.
Al-Khersan H, et al.
Graefe'S Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 255(8), 1613-1619 (2017)
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