SAB4300597

Anti-PTK2 (Ab-576/577) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-FADK antibody produced in rabbit, Anti-FAK antibody produced in rabbit, Anti-FAK1 antibody produced in rabbit, Anti-PTK2 protein tyrosine kinase 2 antibody produced in rabbit, Anti-pp125FAK antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~125 kDa
• species reactivity: mouse, human, rat
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (T-Y-Y-K-A)
• NCBI accession no.: NP_005598.3
• UniProt accession no.: Q05397
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PTK2(5747)

Description

Immunogen

Peptide sequence around aa. 574-578/575-579 (T-Y-Y-K-A), according to the protein PTK2.

Features and Benefits

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Target description

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable