Patatin like phospholipase domain containing 3 (PNPLA3) is part of the patatin-like phospholipase family. This transmembrane lipase is made up of 481 amino acids. The gene encoding PNPLA3 is localized on human chromosome 22q13.31.
Immunogen
Peptide with sequence EHDICPKVKSTN, from the internal region of the protein sequence according to NP_473429.2.
Biochem/physiol Actions
Patatin like phospholipase domain containing 3 (PNPLA3) is a triglyceride hydrolase. It has been associated with hepatic steatosis.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Association of patatin-like phospholipase domain-containing protein 3 gene polymorphisms with susceptibility of nonalcoholic fatty liver disease in a Han Chinese population.
Song G
Medicine (2016)
Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese
Takahisa Kawaguchi
PLoS ONE (2012)
Physical activity and sedentary behavior can modulate the effect of the PNPLA3 variant on childhood NAFLD: a case-control study in a Chinese population.
Wang S
BMC Medical Genetics (2016)
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