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R4892

Sigma-Aldrich

Ranakinin

≥97% (HPLC)

Synonym(s):

Lys-Pro-Asn-Pro-Glu-Arg-Phe-Tyr-Gly-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C62H95N17O15S
CAS Number:
139446-71-2
Molecular Weight:
1350.59
MDL number:
MFCD00214390
UNSPSC Code:
12352200
PubChem Substance ID:
24899378

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(O)=O)NC(=O)C3CCCN3C(=O)C(CC(N)=O)NC(=O)C4CCCN4C(=O)C(N)CCCCN)C(N)=O

Biochem/physiol Actions

NK1 tachykinin receptor agonist

Other Notes

Originally isolated from the brain of frog, Rana ridibunda

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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T Badgery-Parker et al.
Peptides, 14(4), 771-775 (1993-07-01)
The tachykinin binding site preferences of neuropeptide gamma (NP gamma), its C-terminal fragments AcNP gamma(3-21), AcNP gamma(5-21), AcNP gamma(7-21), and AcNP gamma(9-21), other mammalian tachykinins, and the nonmammalian tachykinins ranakinin and carassin were examined in membrane binding competition studies. [125I]-Bolton-Hunter
M K Kodjo et al.
Endocrinology, 139(2), 505-512 (1998-02-04)
We have previously shown that the frog adrenal gland is innervated by a dense network of fibers containing ranakinin, one of the endogenous tachykinins in the amphibian Rana ridibunda, and we have found that ranakinin stimulates in vitro corticosteroid secretion
F O'Harte et al.
Journal of neurochemistry, 57(6), 2086-2091 (1991-12-01)
An extract of the whole brain of the frog Rana ridibunda contained high concentrations of substance P-like immunoreactivity, measured with an antiserum directed against the COOH-terminal region of mammalian substance P and neurokinin B-like immunoreactivity, measured with an antiserum directed
M K Kodjo et al.
Endocrinology, 136(8), 3253-3259 (1995-08-01)
The adrenal gland of the frog is innervated by a network of fibers containing two tachykinins (ranakinin and [Leu3,Ile7]neurokinin A), which both stimulate corticosteroid secretion from frog adrenal tissue. The aim of the present study was to determine the mode
M K Kodjo et al.
The Journal of steroid biochemistry and molecular biology, 57(5-6), 329-335 (1996-03-01)
It has recently been shown that the adrenal gland of the frog Rana ridibunda is densely innervated by a network of fibers containing two novel tachykinins, i.e. ranakinin (the counterpart of substance P) and [Leu3, Ile7]neurokinin A. Both ranakinin and
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