R1903

RS 102895 hydrochloride

≥98% (HPLC), powder

• Synonym(s): 1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one
• Empirical Formula (Hill Notation): C₂₁H₂₁F₃N₂O₂ · HCl
• Molecular Weight: 426.86
• MDL number: MFCD08703093
• UNSPSC Code: 12352202
• PubChem Substance ID: 24724588
• NACRES: NA.32

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• mol wt: 426.86 g/mol
• packaging: pkg of 5 mg
• storage condition: desiccated
• color: white
• solubility: DMSO: >10 mg/mL
• storage temp.: 20-25°C
• SMILES string: Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1
• InChI: 1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
• InChI key: KRRISOFSWVKYBF-UHFFFAOYSA-N

Description

General description

RS 102895 hydrochloride is a small molecule antagonist of C-C motif chemokine receptor 2 (CCR2) which belongs to the spiropiperidine (SP) class.

Application

RS 102895 hydrochloride has been used in bromodeoxyuridine (5-bromo-2′-deoxyuridine, BrdU) cell proliferation assay to study effect of IL33 (interleukin 33) on decidual stromal cell proliferation in present of the antagonist and to study the effects of antagonists on the accumulation of bone marrow-derived microglia.

Biochem/physiol Actions

RS 102895 hydrochloride has a high affinity to the β subunit of the C-C motif chemokine receptor 2 (CCR2) and binds specifically to it. This results in the inhibition of CCR2 signaling. It also suppresses monocyte recruitment. Hence, RS 102895 may be useful for obstructing the immune suppressive effects of monocytes during early vaccine responses.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)