R1406
RIPK2 (1-299), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
CARD3, CARDIAK, RICK, RIP2
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10 μG
$457.00
About This Item
UNSPSC Code:
51111800
NACRES:
NA.32
Recommended Products
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
17-23 nmol/min·mg
mol wt
~59 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... RIPK2(8767)
General description
Receptor interacting serine/threonine kinase 2 (RIPK2) or RICK is a serine/threonine kinase.[1] It contains a kinase domain at the amino-terminal, an intermediate domain and a caspase activation and recruitment domain (CARD) at the carboxy-terminal.[2] The gene encoding RIPK2 is localized on human chromosome 8q21.3.[3]
Biochem/physiol Actions
Receptor interacting serine/threonine kinase 2 (RIPK2) or RICK is activated during innate immune responses and acts as a scaffold for downstream effectors.[4] It functions in nuclear factor-κB (NFκB) activation pathways.[1] The protein also has roles in toll-like receptor (TLR)-signaling pathways and in the production of inflammatory cytokines.[5]
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Knockdown of receptor-interacting serine/threonine protein kinase-2 (RIPK2) affects EMT-associated gene expression in human hepatoma cells.
Wu S
Anticancer Research, 3775-3783 (2012)
N Inohara et al.
The Journal of biological chemistry, 273(20), 12296-12300 (1998-06-20)
Signaling through the CD95/Fas/APO-1 death receptor plays a critical role in the homeostasis of the immune system. RICK, a novel protein kinase that regulates CD95-mediated apoptosis was identified and characterized. RICK is composed of an N-terminal serine-threonine kinase catalytic domain
RIP2, a checkpoint in myogenic differentiation.
Munz B
Molecular and Cellular Biology (2002)
Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.
Rohit Mehra
The American Journal of Pathology (2014)
Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
Pellegrini E
PLoS ONE (2017)
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