Skip to Content
MilliporeSigma
All Photos(1)

Documents

P9018

Sigma-Aldrich

Phorbol 12,13-didecanoate

solid

Synonym(s):

PDD, Phorbol 12,13-dicaprinate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C40H64O8
CAS Number:
24928-17-4
Molecular Weight:
672.93
Beilstein/REAXYS Number:
6036113
MDL number:
MFCD00065449
UNSPSC Code:
12352200
PubChem Substance ID:
24899003

form

solid

color

white

solubility

DMSO: soluble
ethanol: soluble
methanol: soluble

storage temp.

−20°C

SMILES string

[H][C@@]12C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@]3([H])[C@@]1(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCC)[C@]4(OC(=O)CCCCCCCCC)C2C4(C)C

Looking for similar products? Visit Product Comparison Guide

General description

More potent than phorbol myristate acetate as an inflammatory agent, but weaker as a tumor promoting agent

Biochem/physiol Actions

Strong NO promoter; potent activator of protein kinase C; promotes iNOS expression in cultured hepatocytes.

Caution

Photosensitive

Reconstitution

A stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

I Magiati et al.
Molecular autism, 6, 40-40 (2015-07-01)
There is growing research evidence that subclinical autistic traits are elevated in relatives of individuals with autism spectrum disorder (ASD), continuously distributed in the general population and likely to share common etiology with ASD. A number of measures have been
K Hu et al.
The American journal of physiology, 276(2 Pt 2), H488-H495 (1999-02-10)
Both protein kinase C (PKC) and adenosine receptor activation have been shown to enhance ATP-sensitive K+ (KATP) channels. The present studies were designed to determine whether PKC mediates adenosine effects on the KATP channel. The dependence of KATP channel activity
Hiroki Kimura et al.
Schizophrenia bulletin, 41(3), 744-753 (2014-10-22)
Nuclear distribution E homolog 1 (NDE1), located within chromosome 16p13.11, plays an essential role in microtubule organization, mitosis, and neuronal migration and has been suggested by several studies of rare copy number variants to be a promising schizophrenia (SCZ) candidate
Liliana Garneata et al.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 25(1), 67-74 (2014-09-15)
Periodontal disease (PDD) was associated with inflammation, malnutrition, and higher mortality in hemodialysis (HD) patients. Cross-sectional observational study, aiming to assess the prevalence of PDD and the possible relationship among PDD, inflammation, and malnutrition in HD patients. Single HD center
Leandro Francisco S Bastos et al.
European journal of pharmacology, 576(1-3), 171-179 (2007-08-28)
Tetracyclines induce anti-inflammatory effects unrelated to their antimicrobial activities. We investigated the effect induced by minocycline and doxycycline in models of nociceptive and inflammatory pain, edema, fever, cell migration and formation of fibrovascular tissue, as these effects have not been
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service