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Key Documents

P8179

Sigma-Aldrich

Pro-Thr-Pro-Ser amide

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C17H29N5O6
CAS Number:
Molecular Weight:
399.44
MDL number:
UNSPSC Code:
12352200

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(O)C(NC(=O)C1CCCN1)C(=O)N2CCCC2C(=O)NC(CO)C(N)=O

Biochem/physiol Actions

Inhibits proteolysis of IgA by Neisseria gonorrheae protease type I

Other Notes

Analog of the hinge region of human IgA2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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S G Wood et al.
Journal of medicinal chemistry, 32(10), 2407-2411 (1989-10-01)
The six series of unique tetrapeptides and their blocked N-acetyl, C-amide, and N-acetyl-C-amide analogues which comprise the hinge region of human IgA1 (Ser224 to Ser240) have been synthesized and tested as inhibitors of the type 1 IgA1 proteinase elaborated by

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