P6628

Pilocarpine nitrate salt

≥98% (HPLC)

• Empirical Formula (Hill Notation): C₁₁H₁₆N₂O₂ · HNO₃
• CAS Number: 148-72-1
• Molecular Weight: 271.27
• Beilstein/REAXYS Number: 4171406
• EC Number: 205-723-7
• MDL number: MFCD00078497
• UNSPSC Code: 12352200
• PubChem Substance ID: 57654548
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]25/D +83°, c = 10 in H₂O(lit.)
• color: white
• solubility: H₂O: 100 mg/mL
• SMILES string: O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
• InChI: 1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
• InChI key: PRZXEPJJHQYOGF-GNAZCLTHSA-N
• Gene Information: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Description

Application

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

Biochem/physiol Actions

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Safety Information

• pictograms: GHS03,GHS06
• signalword: Danger
• hcodes: H272,H302,H330
• pcodes: P210 - P220 - P260 - P264 - P301 + P312 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2
• Storage Class: 5.1B - Oxidizing hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges