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P2607

Sigma-Aldrich

PRE-084

solid

Synonym(s):

2-(4-morpholinethyl)-1-phenylcyclohexanecarboxylate hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H27NO3 · HCl
Molecular Weight:
353.88
MDL number:
MFCD00673883
UNSPSC Code:
12352200
PubChem Substance ID:
24278627
NACRES:
NA.77

form

solid

solubility

H2O: ≤24 mg/mL

SMILES string

Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3

InChI

1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H

InChI key

QUJWFJNHTBKCLU-UHFFFAOYSA-N

Gene Information

human ... OPRS1(10280)
rat ... Oprs1(29336) , Slc6a3(24898)

Biochem/physiol Actions

PRE-084 is a potent and highly selective σ1 opioid receptor agonist. It offers neuroprotection upon embolic stroke.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
Allahtavakoli M and Jarrott B
Brain Research Bulletin, 85(3-4), 219-224 (2011)
Judit Hodrea et al.
International journal of molecular sciences, 24(14) (2023-07-29)
Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor of the disease and it can be caused by fibrotic-like changes in the trabecular meshwork (TM) such as increased
Yuriko Kimura et al.
PloS one, 8(10), e75760-e75760 (2013-10-12)
Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (CNS). For that, it is considered as an
Li-Li Ji et al.
Molecular medicine reports, 16(4), 4987-4993 (2017-08-10)
Accumulating evidence has demonstrated that the σ-1 receptor (σ‑1R) possesses neuroprotective effects and is a potential novel therapeutic target for certain psychiatric diseases, including post‑traumatic stress disorder (PTSD) accompanied with anxiety disorder. It has been reported that σ‑1R agonist treatment
Yan-Lin He et al.
Neuroscience bulletin, 34(5), 759-768 (2018-04-20)
Cyproheptadine (CPH), a first-generation antihistamine, enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway. In this study, we aimed to determine the effects of CPH on neuronal excitability in
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