Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

P0248

Sigma-Aldrich

PNU-37883A

≥98% (HPLC), powder

Synonym(s):

N-(1-Adamantyl)-N′-cyclohexyl-4-morpholinecarboxamidine hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H36ClN3O
CAS Number:
57568-80-6
Molecular Weight:
381.98
MDL number:
MFCD06798347
UNSPSC Code:
12352200
PubChem Substance ID:
24277692

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: ~23 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5

Gene Information

human ... KCNJ8(3764)

Biochem/physiol Actions

Selective inhibitor of Kir6.1/SUR2B channels.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cheng-Yuan Hsu et al.
Shock (Augusta, Ga.), 37(6), 653-658 (2012-05-04)
In clinical practice, prolonged occlusion of main arteries causes accumulation of metabolic waste and lactate. Reperfusion of blood flow is usually accompanied by circulatory shock. This study investigates the molecular mechanisms responsible for acidosis-induced hypotension and proposes therapeutic strategies for
Yoshihiro Suzuki et al.
International journal of oncology, 41(2), 465-475 (2012-05-23)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, drugs that can amplify TRAIL cytotoxicity
Salma Toma Hanna et al.
European journal of pharmacology, 515(1-3), 34-42 (2005-05-17)
Kir6.1 subunit is one of the pore-forming components of K(ATP) channel complex. The endogenous modulation of Kir6.1 subunit function has been largely unknown. Whether acetylcholine modulated the function of Kir6.1 subunit stably expressed in human embryonic kidney (HEK-293) cells was
Toshihisa Tomoda et al.
European journal of pharmacology, 524(1-3), 1-10 (2005-10-26)
The effects of U-37883A, a vascular ATP-sensitive K(+) channel (K(ATP) channel) blocker, on membrane currents were investigated in pig urethral myocytes by use of patch-clamp techniques (conventional whole-cell recordings, nystatin-perforated patches and cell-attached configuration). Tension measurement was also performed to
Bo Jiang et al.
European journal of pharmacology, 577(1-3), 124-128 (2007-10-24)
Sulphonylureas, such as glybenclamide and gliclazide, are classical blockers of ATP-dependent potassium channels (K(ATP)). Closure of K(ATP) channels in vascular smooth muscles by sulphonylureas would lead to membrane depolarization and vasoconstriction but this hypothesis has not been consistently proved in
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service