O2501
Ornithine Transcarbamylase from Streptococcus faecalis
lyophilized powder, ≥300 units/mg protein
Synonym(s):
Carbamoylphosphate:L-Ornithine Carbamoyltransferase, OTCase, Ornithine Carbamoyl Transferase
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About This Item
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form
lyophilized powder
Quality Level
specific activity
≥300 units/mg protein
composition
Protein, ≥65% Lowry
storage temp.
−20°C
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Biochem/physiol Actions
Mutations in ornithine transcarbamylase cause Ornithine transcarbamylase deficiency which prevents the clearance of the byproduct ammonia leading to hyperammonemia. [1]
Unit Definition
One unit will form 1.0 μmole of citrulline from ornithine and carbamyl phosphate per min at pH 8.5 at 37 °C.
Physical form
Lyophilized powder contains Tris buffer salts
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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I G Shabalin et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 68(Pt 9), 1018-1024 (2012-09-06)
Anabolic ornithine transcarbamoylase (aOTC) catalyzes the reaction between carbamoyl phosphate (CP) and L-ornithine (ORN) to form L-citrulline and phosphate in the urea cycle and L-arginine biosynthesis. The crystal structure of unliganded aOTC from Campylobacter jejuni (Cje aOTC) was determined at
Eddy C Hsueh et al.
Journal of hematology & oncology, 5, 17-17 (2012-05-02)
Recombinant human arginase (rhArg) has been developed for arginine deprivation therapy in cancer, and is currently under clinical investigation. During pre-clinical evaluation, rhArg has exhibited significant anti-proliferative activity in cancer cells deficient in the expression of ornithine carbamoyl transferase (OCT).
QnAs with Arthur L. Horwich. Interview by Prashant Nair.
Arthur L Horwich
Proceedings of the National Academy of Sciences of the United States of America, 109(9), 3193-3193 (2012-02-07)
Hari Iyer et al.
Hemodialysis international. International Symposium on Home Hemodialysis, 16(1), 95-100 (2011-11-22)
Urea cycle disorders are an important and treatable cause of hyperammonemia in the newborn and pediatric age group. Presentation in adolescence or adult life is rare and can manifest as frequent vomiting and behavioral changes. An inherited metabolic disorder should
Tatjana Skrbić et al.
PLoS computational biology, 8(6), e1002504-e1002504 (2012-06-22)
Stochastic simulations of coarse-grained protein models are used to investigate the propensity to form knots in early stages of protein folding. The study is carried out comparatively for two homologous carbamoyltransferases, a natively-knotted N-acetylornithine carbamoyltransferase (AOTCase) and an unknotted ornithine
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