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N1773

Sigma-Aldrich

[Ser2]-Neuromedin C

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C49H72N16O11S
CAS Number:
136058-54-3
Molecular Weight:
1093.26
MDL number:
MFCD00214338
UNSPSC Code:
12352202
PubChem Substance ID:
24897526
NACRES:
NA.26

product name

[Ser2]-Neuromedin C, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

solid

composition

Peptide content, ~70%

UniProt accession no.

P07492

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc4cnc[nH]4)NC(=O)C(CO)NC(=O)CN)C(C)C)C(N)=O

InChI

1S/C49H72N16O11S/c1-25(2)13-34(45(72)61-33(42(51)69)11-12-77-6)62-46(73)36(15-29-19-52-23-56-29)59-40(68)21-55-49(76)41(26(3)4)65-43(70)27(5)58-44(71)35(14-28-18-54-32-10-8-7-9-31(28)32)63-47(74)37(16-30-20-53-24-57-30)64-48(75)38(22-66)60-39(67)17-50/h7-10,18-20,23-27,33-38,41,54,66H,11-17,21-22,50H2,1-6H3,(H2,51,69)(H,52,56)(H,53,57)(H,55,76)(H,58,71)(H,59,68)(H,60,67)(H,61,72)(H,62,73)(H,63,74)(H,64,75)(H,65,70)

InChI key

CDSKUMVQOSVSRF-UHFFFAOYSA-N

Gene Information

human ... GRP(2922)

Amino Acid Sequence

Gly-Ser-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2

Biochem/physiol Actions

[Ser2]-Neuromedin C is a bombesin-like peptide known to inhibit feeding.

Other Notes

Bombesin-like peptide originally isolated from the brain of the European green frog, Rana ridibunda.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Eva Mónika Fekete et al.
Brain research bulletin, 71(4), 386-392 (2007-01-09)
Bombesin-like peptides including gastrin releasing peptide and neuromedin C are known to inhibit feeding. Bombesin receptors have been found in moderate to high densities in the amygdaloid body, which is essentially involved in the regulation of feeding and body weight.
Biochemical and Biophysical Research Communications, 178, 529-529 (1991)

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