This kit is sufficient to perform 100 tests in a 96-well plate format, including standards and duplicates. Please see the link below to review the product data sheet: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/125/489/mak257bul.pdf
MAK257
Tyrosinase Inhibitor Screening Kit (Colorimetric)
sufficient for 100 colorimetric tests
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12161503
NACRES:
NA.25
Recommended Products
application(s)
cosmetics
food and beverages
detection method
colorimetric
relevant disease(s)
dermatological diseases
storage temp.
−20°C
General description
Tyrosinase or polyphenol oxidase (EC 1.14.18.1), is an oxidoreductase that participates in the biosynthesis of melanin, a ubiquitous biological pigment found in hair, eyes, skin, etc. Inhibition of tyrosinase has been a long-time target in the skin health research, cosmetics and agricultural industries because of its role in browning reactions in skin pigmentation and during fruit harvesting and handling. Skin whitening and bleaching products utilize natural or synthetic tyrosinase inhibitors in order to lighten the skin color. Polyphenols, benzaldehyde derivatives, long-chain lipids, steroids, and natural compounds have been used as tyrosinase inhibitors.
Deficiency in tyrosinase causes albino, a condition in which the melanocytes are not able to produce melanin. This increases the risk of skin cancer.[1]
Deficiency in tyrosinase causes albino, a condition in which the melanocytes are not able to produce melanin. This increases the risk of skin cancer.[1]
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for screening/studying/characterizing tyrosinase inhibitors.
Principle
Tyrosinase catalyzes the oxidation of tyrosine, producing a chromophore that can be detected at 510 nm. In the presence of kojic acid, a reversible inhibitor of tyrosinase, the rate of oxidation of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of tyrosinase inhibitors. The assay is also adaptable to a 384 well format.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Resp. Sens. 1
Storage Class
10 - Combustible liquids
flash_point_f
188.6 °F
flash_point_c
87 °C
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
OP-25 Practical Applications of Systems Biology Bioinformatics in Translational Science and Drug Discovery.
Erhan S.
3rd INTERNATIONAL BAU-DRUG DESIGN CONGRESS, 94-94 (2015)
Vinay Bhardwaj et al.
Frontiers in medicine, 8, 617068-617068 (2021-03-09)
Chemical peeling is usually performed by dermatologists, plastic surgeons, and aestheticians for the treatment of photo-aged skin, dyspigmented skin, skin prone to acne eruption, and pre-cancerous skin lesions, etc. In this research paper, we report our investigative findings to understand
-
How many analisys this kit provide?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
