immunocytochemistry: 4 μg/mL using human brain, caudate immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4 μg/mL using human brain, caudate
synthetic peptide corresponding to the N-terminal extracellular domain of human melanocortin 4 receptor. The immunizing peptide has 94% homology with the rat and mouse gene.
Biochem/physiol Actions
Melanocortin 4 receptor (MC4R) is an important regulator of food intake and body weight in mammals. It also regulates energy homeostasis in response to neuropeptides. Polymorphisms in MC4R gene or haploinsufficiency results in early onset obesity in humans also termed melanocortin obesity syndrome.
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The melanocortins, a family of peptides produced from the post-translational processing of pro-opiomelanocortin (POMC), regulate ingestive behavior and energy expenditure. Loss of function mutations of genes encoding POMC, or of either of two melanocortin receptors expressed in the central nervous
British journal of pharmacology, 149(7), 815-827 (2006-10-18)
Mutations in the human melanocortin (MC)4 receptor have been associated with obesity, which underscores the relevance of this receptor as a drug target to treat obesity. Infusion of MC4R agonists decreases food intake, whereas inhibition of MC receptor activity by
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7050-7055 (2013-04-10)
Haploinsufficiency of the melanocortin-4 receptor (MC4R) results in melanocortin obesity syndrome, the most common monogenic cause of severe early onset obesity in humans. The syndrome, which produces measurable hyperphagia, has focused attention on the role of MC4R in feeding behavior
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