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Key Documents

L9773

Sigma-Aldrich

Luteinizing Hormone from equine pituitary

pkg of ~15 units/vial

Synonym(s):

ICSH, LH, PLH

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About This Item

CAS Number:
9002-67-9
EC Number:
232-661-8
MDL number:
MFCD00131550
UNSPSC Code:
51111800

form

powder

Quality Level

200

packaging

pkg of ~15 units/vial

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

UniProt accession no.

A0A3Q2I386
P08751

shipped in

ambient

storage temp.

2-8°C

Gene Information

horse ... LHB(100054774) , LHCGR(100034043)

Application

Luteinizing hormone (LH) has been used to study effect of LH on the development of preantral follicles for nuclear maturation of ovine oocytes and as an endocrine signal to study circadian phase in the ovary.

Biochem/physiol Actions

Two chain glycoprotein hormone, the α-chain is not active, biological specificity is attributed to the β-chain; induces ovulation, spermatogenesis, and synthesis of sex steroids.

Packaging

Package size based on NIH standard LH-S1 using the rat Leydig cell assay

Quantity

One NIH LH-S1 unit = approx. 2,000 I.U.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360F

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nuclear maturation of ovine oocytes in cultured preantral follicles
G Tamilmani
The Journal of Small Animal Practice (2005)
Timing of the Ovarian Circadian Clock Is Regulated by Gonadotropins
Tomoko Y
Endocrinology (2009)
Tomoko Yoshikawa et al.
Endocrinology, 150(9), 4338-4347 (2009-06-13)
The timing of ovulation is critically important to the success of reproduction. Current thinking attributes the timing of ovulation to LH secretion by the pituitary, itself timed by signals from the hypothalamus. The discovery of an internal circadian timer in
Rachel Y Cheong et al.
Endocrinology, 155(4), 1418-1427 (2014-01-31)
The negative feedback mechanism through which 17β-estradiol (E2) acts to suppress the activity of the GnRH neurons remains unclear. Using inducible and cell-specific genetic mouse models, we examined the estrogen receptor (ER) isoforms expressed by neurons that mediate acute estrogen
Hidetoshi Hasuwa et al.
Science (New York, N.Y.), 341(6141), 71-73 (2013-06-15)
Ovulation in the mouse and other mammals is controlled by hormones secreted by the hypothalamo-pituitary-ovarian axis. We describe anovulation and infertility in female mice lacking the microRNAs miR-200b and miR-429. Both miRNAs are strongly expressed in the pituitary gland, where
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