L1381
L-α-Lysophosphatidylcholine from bovine brain
≥99%, Type V
Synonym(s):
1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
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About This Item
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description
zwitterionic
type
Type V
assay
≥99%
lipid type
phospholipids
storage temp.
−20°C
General description
Application
L-α-Lysophosphatidylcholine from bovine brain has been used:
- to determine the dose-dependent high-mobility group box 1 (HMGB1) release in macrophage and monocyte cultures by production of lysophosphatidylcholine (LPC)[3]
- for lysolecithin demyelination of mice brain tissue[4]
- for demyelination of axons[5]
Biochem/physiol Actions
L-α-Lysophosphatidylcholine possess cytotoxic effects and is present at high level in ischemia and atherosclerotic aortas.[2]
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis.
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is a degradation product of phosphatidylcholine by phospholipase A and has cytolytic properties. The product is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.
Features and Benefits
This compound is featured on the Phospholipase D page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes
Contains primarily palmitic, stearic and oleic acids.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis
Chen G, et al.
Journal of Lipid Research, 46(4), 623-627 (2005)
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Metabolism and atherogenic disease association of lysophosphatidylcholine
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