I0654
Interleukin-1 Soluble Receptor, Type I human
>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
(IL-1 sRI)
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About This Item
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biological source
human
Quality Level
recombinant
expressed in NSO cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
mol wt
36 kDa
packaging
pkg of 0.1 mg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL1R1(3554)
General description
Interleukin-1 type 1 receptor (IL1R1) is a glycoprotein. It is mainly expressed on endothelial cells, epithelial cells, hepatocytes, fibroblasts, epidermal dendritic cells as well as T lymphocytes.
Biochem/physiol Actions
Interleukin-1 (IL-1), a cytokine, is a key regulator of acute and chronic inflammation. The IL-1 associated responses are achieved by association of IL-1 with IL-1 type 1 receptor (IL1R1).
Recombinant human IL-1 soluble receptor I is a transmembrane protein and a member of the immunoglobulin superfamily. It is expressed predominantly by T cells, fibroblasts, and endothelial cells.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5.0 mg bovine serum albumin
Analysis Note
The bioactivity is measured by its ability to inhibit the IL-1β-dependent proliferation of a murine helper T cell line, D10.G4.1.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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F F Vasilyev et al.
Cellular & molecular immunology, 12(2), 222-230 (2014-07-01)
The biological activity of the multifunctional cytokine interleukin-1 (IL-1) is mediated by its receptors. The aim of this study was to determine if an association exists between single nucleotide polymorphisms (SNPs) in the IL-1 type 1 and 2 receptor genes
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