HPA023644

Anti-STAR antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab1

• Synonym(s): Anti-NET29, Anti-STARD1, Anti-TMPIT, Anti-steroidogenic acute regulatory protein
• UNSPSC Code: 12352203
• Human Protein Atlas Number: HPA023644
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• product line: Prestige Antibodies^® Powered by Atlas Antibodies
• form: buffered aqueous glycerol solution
• species reactivity: human
• enhanced validation: independent; orthogonal RNAseq; Learn more about Antibody Enhanced Validation
• technique(s): immunohistochemistry: 1:200-1:500
• immunogen sequence: QDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELA
• UniProt accession no.: P49675
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... STAR(6770)

Description

General description

Steroidogenic acute regulatory protein is located on human chromosome 8p11.2.

Immunogen

steroidogenic acute regulatory protein recombinant protein epitope signature tag (PrEST)

Application

Anti-STAR antibody produced in rabbit has been used to detect StAR in Paraffin-embedded adrenal samples using immunohistochemistry.

Biochem/physiol Actions

Steroidogenic acute regulatory protein (StAR) is essential for the transfer of cholesterol to mitochondria for adrenal and gonadal steroidogenesis. StAR gene analysis can help in the diagnosis of lipoid congenital adrenal hyperplasia (LCAH). It is also identified that activins A,B,AB downregulates StAR and thereby reduces the production of progesterone in human granulosa cells. Hypoxia mediated upregulation of StAR stimulates the synthesis of aldosterone in pulmonary artery endothelial cells which contributes to pulmonary vascular fibrosis. Activation of StAR helps in prevention of atherosclerotic cardiovascular disease.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST76259

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable