G5297

Glp-Asn-Pro-d-Tyr-d-Trp-NH2

≥98% (HPLC), solid

• Synonym(s): JAK4D
• Empirical Formula (Hill Notation): C₃₄H₄₀N₈O₈
• CAS Number: 882400-49-9
• Molecular Weight: 688.73
• MDL number: MFCD11114385
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799939

Properties

• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: H₂O: >2 mg/mL
• storage temp.: −20°C
• SMILES string: NC(=O)C[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc3ccc(O)cc3)C(=O)N[C@H](Cc4c[nH]c5ccccc45)C(N)=O
• InChI: 1S/C34H40N8O8/c35-28(44)16-26(41-31(47)23-11-12-29(45)38-23)34(50)42-13-3-6-27(42)33(49)40-25(14-18-7-9-20(43)10-8-18)32(48)39-24(30(36)46)15-19-17-37-22-5-2-1-4-21(19)22/h1-2,4-5,7-10,17,23-27,37,43H,3,6,11-16H2,(H2,35,44)(H2,36,46)(H,38,45)(H,39,48)(H,40,49)(H,41,47)/t23-,24+,25+,26-,27-/m0/s1
• InChI key: SZQSOKVXBMULDL-VQHLWIOESA-N
• Gene Information: rat ... TRH(7200) , TRHDE(29953) , TRHR(7201)

Description

Amino Acid Sequence

Glp-Asn-Pro-Tyr-Trp-NH2

Biochem/physiol Actions

The synthetic peptide Glp-Asn-Pro-d-Tyr-d-Trp-NH2 mimics and amplifies central actions of TRH in rat without releasing TSH. Glp-Asn-Pro-d-Tyr-d-Trp-NH2 has dual pharmacological activities: it inhibits TRH-DE and binds to central TRH receptors with nM affinity in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRH receptor 1 (TRHR1) or TRH receptor 2 (TRHR2). The peptide can be a potent tool for probing the role of TRH actions in the CNS and a platform for development of novel TRH-based therapeutics for neuro diseases.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)