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FGFR3 (397-end), active, GST tagged human

Name: FGFR3 (397-end), active, GST tagged human
Brand: SIGMA
Price: 576 USD

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

Eph receptor tyrosine kinase, growth hormone receptor, ACH, CD333, CEK2, HSFGFR3EX, JTK4

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Pack Size	SKU	Availability	Price
10 μg		Check Cart for Availability	$576.00

About This Item

NACRES:

NA.32

UNSPSC Code:

51111800

Form:

buffered aqueous glycerol solution

Assay:

≥70% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in baculovirus infected Sf9 cells

Mol wt:

~73 kDa

$576.00

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biological source

human

Quality Level

200

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO^® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

95-129 nmol/min·mg

mol wt

~73 kDa

packaging

pkg of 10 μg

technique(s)

cell based assay: suitable

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Show Differences

1 of 1

This Item	SRP5301	F6432	F8055
Sigma-Aldrich F7930 FGFR3 (397-end), active, GST tagged human	Sigma-Aldrich SRP5301 FGFR3 (K650E), active, GST tagged human	Sigma-Aldrich F6432 FLT3 (571-993), active, GST tagged human	Sigma-Aldrich F8055 FGR, active, GST tagged human
technique(s) cell based assay: suitable	technique(s) -	technique(s) -	technique(s) -
recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells
biological source human	biological source -	biological source -	biological source -
assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)
form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
packaging pkg of 10 μg	packaging -	packaging -	packaging -

General description

Research area: Cancer

FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.[1]FGFR3 has a strong affinity for canonical FGF ligands.

Biochem/physiol Actions

FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. [2] This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma [2] and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.[3]Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. [2] FGFR3 also plays hepatoprotective function during liver damage. [4]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Coupling of transmembrane helix orientation to membrane release of the juxtamembrane region in FGFR3.

Hiroko Tamagaki et al.

Biochemistry, 53(30), 5000-5007 (2014-07-11)

Activation of the protein tyrosine kinase receptors requires the coupling of ligand binding to a change in both the proximity and orientation of the single transmembrane (TM) helices of receptor monomers to allow transphosphorylation of the receptor kinase domain. We

FGFR3 biology and skeletal disease

Jyoti Narayana and William A Horton

Connective tissue research, 56(6), 427-433 (2015)

Roles of FGF signaling in skeletal development and human genetic diseases.

Lin Chen et al.

Frontiers in bioscience : a journal and virtual library, 10, 1961-1976 (2005-03-17)

Fibroblast growth factor receptors (FGFRs) exist as a gene family of 4 membrane bound receptor tyrosine kinases (FGFR1-4) that mediate signals of at least 22 fibroblast growth factors (FGF1-22). FGFs/FGFRs play important roles in multiple biological processes, including mesoderm induction

FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder.

Elizabeth A Guancial et al.

Cancer medicine, 3(4), 835-844 (2014-05-23)

While fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC), the prevalence of FGFR3 protein expression and mutation remains unknown in muscle-invasive disease. FGFR3 protein and mRNA expression, mutational status, and copy number

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis.

Corine G M L'Hôte et al.

Experimental cell research, 304(2), 417-431 (2005-03-08)

FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a negative regulatory effect on long bone growth. Fgfr3 knockout mice display longer bones and, accordingly, most germline-activating mutations in man are associated with dwarfism.

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Global Trade Item Number

SKU	GTIN
F7930-10UG	04061837904967

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