F6807

Fleroxacin

• Synonym(s): RO 23-6240, 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid, 6,8-Difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, AM-833, Megalocin, Megalone
• Empirical Formula (Hill Notation): C₁₇H₁₈F₃N₃O₃
• CAS Number: 79660-72-3
• Molecular Weight: 369.34
• NACRES: NA.85
• PubChem Substance ID: 329799758
• UNSPSC Code: 51102829
• MDL number: MFCD00864880

Properties

• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: 0.1 M NaOH: 10 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: −20°C
• SMILES string: CN1CCN(CC1)c2c(F)cc3C(=O)C(=CN(CCF)c3c2F)C(O)=O
• InChI: 1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
• InChI key: XBJBPGROQZJDOJ-UHFFFAOYSA-N

Description

Application

Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It is used in pharmacokinetic studies and is used to study the treatment of intra-abdominal abscesses and travellers′ diarrhea.

Biochem/physiol Actions

Fleroxacin is a synthetic trifluorinated quinolone with antimicrobial activity against a variety of pathogens, including mycobacteria, mycoplasmas, chlamydiae, and legionellae. It strongly inhibits the DNA-supercoiling activity of DNA gyrase and DNA topoisomerase 2, which results in cell death.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable