Skip to Content
MilliporeSigma
All Photos(1)

Documents

F1183

Sigma-Aldrich

FK888 hydrate

Synonym(s):

FK888 hydrate, (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate, N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C36H36N4O4 · xH2O
CAS Number:
138449-07-7
Molecular Weight:
588.70 (anhydrous basis)
MDL number:
MFCD19686961
UNSPSC Code:
12352200
PubChem Substance ID:
329799676
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -135 to -145°, c = 1 in methanol

color

white to tan

solubility

DMSO: ≥13 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

O.CN(Cc1ccccc1)C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]4C[C@@H](O)CN4C(=O)c5cc6ccccc6n5C

InChI

1S/C36H36N4O4.H2O/c1-38(22-24-10-4-3-5-11-24)35(43)30(19-25-16-17-26-12-6-7-13-27(26)18-25)37-34(42)32-21-29(41)23-40(32)36(44)33-20-28-14-8-9-15-31(28)39(33)2;/h3-18,20,29-30,32,41H,19,21-23H2,1-2H3,(H,37,42);1H2/t29-,30+,32+;/m1./s1

InChI key

QOMUXFWVTKDGGK-ZGCLDRINSA-N

Biochem/physiol Actions

Selective, high affinity tachykinin NK1 receptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

E C Gavioli et al.
Behavioural brain research, 134(1-2), 411-415 (2002-08-23)
The lateral septal nucleus (LS) presents a dense plexus of fibers containing substance P (SP), which is known to induce pronounced anxiogenic-like effects when applied into this brain site. In the present report, we investigated the role of lateral septal
Y Kamijo et al.
Life sciences, 70(1), 1-15 (2002-01-05)
To evaluate whether neutral endopeptidase (NEP) inhibitors have adverse respiratory effects, the influence of a NEP inhibitor on bradykinin (BK)-induced bronchoconstriction was investigated. In anesthetized and artificially ventilated guinea pigs, changes in airway opening pressure (Pao) were measured as an
Raquel M Teixeira et al.
Neuropeptides, 37(5), 307-315 (2003-11-11)
This study investigated the influence of a selective tachykinin NK(1) receptor antagonist FK888 on the performance of mice in the elevated plus-maze test and on peripheral blood count after central treatment with substance P (SP) compared to animals submitted to
Hironobu Fukuda et al.
International archives of allergy and immunology, 152(3), 295-300 (2010-02-13)
Although neurogenic inflammation of the airways via activation of C-fibers is thought to be important in the pathogenesis of asthma, the mechanisms regulating C-fiber activity remain uncertain. The influence of a cannabinoid receptor agonist, WIN 55,212-2, on C-fiber activation in
Mariem El Sayah et al.
Peptides, 24(7), 1045-1051 (2003-09-23)
We have reported previously that bradykinin (BK) induces potent and reproducible concentration-dependent contractions of the pig iris sphincter (PIS) muscle in vitro through the activation of BK B(2) receptors. Here we attempted to investigate additional mechanisms by which BK induces
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service