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Key Documents

COO/COA

EMU186351

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting mouse Lin28a

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About This Item

UNSPSC Code:

41105324

NACRES:

NA.51

description

Quality Level

100

product line

MISSION^®

form

lyophilized powder

esiRNA cDNA target sequence

ACCCGAGGCTCTCTATCTCCAGCTACAGAGTGAGGCCCTGTCTCAAAACCACCAACCAAAACTCTTCACTGAGTTAGGGACAAGGAAAGAATGAGGTTCCTGGCTTCTTCAGAATTTTCACATGGGTCCTTCAAGAGTTACAGAGATGCTCAAAGAAGTAAATGAGCCTAAGTTTTCTTACGAGGGAGAAGAGGGGCTGTCTGAAGGTCACTGTGGTCCAGAATGGGAGACACAGGAGGAACAGGTAAGGATAAGCCATGGTCCCAGAGGTTCACTTTGAGAAGAGGACCGCACATTTAAGTTTCAGATGGTGTTGTCTGGTGCAGAGCTTTCTGTCAAAGATGCTTTGGCTATTTTTCTCTCAATACAACAAAAGTTTTGTAAACAATAAAACCCCAAAAGAACATGAAGACCAACACATTTATATTTACACAACTAGGCCACCTAGCAATCACCAACTCAGAGACAGTAAAAGTCCTACAAAGGCCAGACGAATACAATTAACTAGGGGTGAGGGC

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... LIN28A(83557)

Related Categories

MISSION® esiRNA

Oligos, qPCR Probes & Peptides

General description

MISSION^® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.

Hao Zhu et al.

Nature genetics, 42(7), 626-630 (2010-06-01)

Recently, genome-wide association studies have implicated the human LIN28B locus in regulating height and the timing of menarche. LIN28B and its homolog LIN28A are functionally redundant RNA-binding proteins that block biogenesis of let-7 microRNAs. lin-28 and let-7 were discovered in

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