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EHU094831

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human CCDC85C, CCNK

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About This Item

UNSPSC Code:

41105324

NACRES:

NA.51

description

product line

MISSION^®

form

lyophilized powder

esiRNA cDNA target sequence

AGTGGGTAAGCAGCAGGGTACCTTGTATAATGCACGACAGTTGCAGTATGGGAAGAATGGACCGGGCCCCTGGGATAAAATCAGAGTGGTCCTCACACCTAGAGGACGGGGACAACCAGCTTTCAGAGTAGCCTCATCAGTGCCCTTGCAGTCTGACTGTGTACACTTGGTTCAGCTAATGTCTGAGAGTCCTGCACTGGGTTACTTTATACTAGTGAGGACGTTAACCAGCCATATTGGCTCAATAAATAGCTTCGGTAAGGAGTTAATTTCCTTCTAGAAATCAGTGCCTATTTTTCCTGGAAACTCAATTTTAAATAGTCCAATTCCATCTGAAGCCAAGCTGTTGTCA

Ensembl | human accession no.

ENSG00000090061

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... CCDC85C(317762) , CCNK(8812)

Related Categories

MISSION® esiRNA

Oligos, qPCR Probes & Peptides

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Cyclin K dependent regulation of Aurora B affects apoptosis and proliferation by induction of mitotic catastrophe in prostate cancer.

Sabrina Schecher et al.

International journal of cancer, 141(8), 1643-1653 (2017-07-04)

Cyclin K plays a critical role in transcriptional regulation as well as cell development. However, the role of Cyclin K in prostate cancer is unknown. Here, we describe the impact of Cyclin K on prostate cancer cells and examine the

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.

Kingsley M Ekumi et al.

Nucleic acids research, 43(5), 2575-2589 (2015-02-26)

The Cdk12/CycK complex promotes expression of a subset of RNA polymerase II genes, including those of the DNA damage response. CDK12 is among only nine genes with recurrent somatic mutations in high-grade serous ovarian carcinoma. However, the influence of these

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