E0886
Ebelactone B microbial
≥95% (HPLC)
Synonym(s):
2-Ethyl-3,11-dihydroxy-4,6,8,10,12-pentamethyl-9-oxo-6-tetradecenoic acid 1,3-lactone
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About This Item
Empirical Formula (Hill Notation):
C21H36O4
CAS Number:
Molecular Weight:
352.51
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
assay
≥95% (HPLC)
storage temp.
2-8°C
SMILES string
[H][C@]1(OC(=O)[C@H]1CC)[C@@H](C)C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@H](C)CC
Biochem/physiol Actions
Esterase (lipase) inhibitor. Also inhibits carboxypeptidase Y-like kininase that degrades bradykinin.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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M Katori et al.
Biological research, 31(3), 143-149 (1998-11-27)
Tissue kallikrein and low molecular weight kininogen are localized in the particular cells of the connecting tubules, indicating that kinin is immediately generated in the lumina of the lower nephrons. The role of the renal kallikreinkinin system was studied using
M Saito et al.
International journal of tissue reactions, 17(5-6), 181-190 (1995-01-01)
Incubation of bradykinin with human urine resulted in a successive degradation of bradykinin-(1-8), bradykinin-(1-7), bradykinin-(1-6), and bradykinin-(1-5). Although D,L-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (100 microM) and captopril (100 microM) did not have any significant effect on bradykinin degradation in human urine, the neutral
M Majima et al.
European journal of pharmacology, 284(1-2), 1-11 (1995-09-15)
Kininogen-deficient Brown Norway Katholiek rats (BN-Ka) excrete little urinary kinin, compared with normal rats of the same strain (BN Kitasato rats (BN-Ki)). Deoxycorticosterone acetate-salt treatment increased systolic blood pressure in both rats, but much faster in BN-Ka than in BN-Ki.
M Katori et al.
Immunopharmacology, 36(2-3), 237-242 (1997-06-01)
Role of renal kallikrein-kinin system has been studied using mutant Brown-Norway Katholiek (BN-Ka) rats, in which both high- and low-molecular weight kininogens were almost absent in plasma and kinin in urine was mainly not detectable. Mutant BN-Ka rats were very
T Kajiro et al.
Analytical biochemistry, 297(1), 52-59 (2001-09-25)
Bradykinin (BK) in rat urine was determined by coupled-column HPLC with precolumn fluorogenic derivatization with a water-soluble reagent, 3-(7-fluoro-2,1,3-benzoxadiazole-4-sulfonamido)benzenesulfonic acid (m-BS-ABD-F). The derivatization of BK with m-BS-ABD-F was completed at 70 degrees C for 100 min and gave only a
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