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D7644

Sigma-Aldrich

Disopyramide

Synonym(s):

α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide

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About This Item

Empirical Formula (Hill Notation):
C21H29N3O
CAS Number:
3737-09-5
Molecular Weight:
339.47
EC Number:
223-110-2
MDL number:
MFCD00057366
UNSPSC Code:
12352200
PubChem Substance ID:
24278384

SMILES string

CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C

InChI

1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)

InChI key

UVTNFZQICZKOEM-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544) , KCNH1(3756) , SCN5A(6331)

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Biochem/physiol Actions

Class IA antiarrhythmic; sodium channel blocker

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

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J P Fauchier et al.
Archives des maladies du coeur et des vaisseaux, 84(4), 553-560 (1991-04-01)
Moricizine chlorhydrate (Ethmozine), a relatively unknown antiarrhythmic agent in France, is a derivative of Phenothiazine, related to the Vaughan-Williams Class IB drugs. A randomised, double-blind, crossover trial with Disopyramide 600 mg/day after a placebo period in 10 patients with ventricular
Procainamide and disopyramide.
C Ribeiro et al.
European heart journal, 8 Suppl A, 11-19 (1987-03-01)
Katsuya Kajimoto et al.
The American journal of cardiology, 106(9), 1307-1312 (2010-10-30)
Negative inotropic agents are often administered to decrease the left ventricular (LV) pressure gradient in patients with obstructive hypertrophic cardiomyopathy (HC). Little information is available regarding comparisons of the effects on LV pressure gradient among negative inotropic agents. The present
S Y Kim et al.
Drug safety, 5(6), 393-420 (1990-11-01)
Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their use is associated with a number of serious adverse effects during long term therapy and life-threatening sequelae
Ferdinando Pasquale et al.
Nature reviews. Cardiology, 6(4), 313-316 (2009-04-09)
A 61-year-old man presented with shortness of breath and chest pain on exertion. He had been diagnosed as having hiatus hernia 2 years previously and was taking proton-pump inhibitors as necessary. He had a family history of ischemic heart disease
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