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Key Documents

C9359

Sigma-Aldrich

Z-Ala-Ser-Thr-Asp(OMe)-fluoromethyl ketone

≥90% (TLC), solid

Synonym(s):

EMAP II inhibitor

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About This Item

Empirical Formula (Hill Notation):
C24H33N4O10F
CAS Number:
Molecular Weight:
556.54
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥90% (TLC)

form

solid

storage temp.

−20°C

SMILES string

COC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)[C@@H](C)O)C(=O)CF

InChI

1S/C24H33FN4O10/c1-13(26-24(37)39-12-15-7-5-4-6-8-15)21(34)28-17(11-30)22(35)29-20(14(2)31)23(36)27-16(18(32)10-25)9-19(33)38-3/h4-8,13-14,16-17,20,30-31H,9-12H2,1-3H3,(H,26,37)(H,27,36)(H,28,34)(H,29,35)/t13-,14+,16-,17-,20-/m0/s1

InChI key

LICIOVKJUZZCAM-ACSCVQKFSA-N

Amino Acid Sequence

Z-Ala-Ser-Thr-Asp(OMe)-FMK

Biochem/physiol Actions

Cell-permeable inhibitor of endothelial monocyte-activating polypeptide II (EMAP-II).

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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U E Knies et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(21), 12322-12327 (1998-10-15)
Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for monocytes. We show here that, in the mouse embryo, EMAP II mRNA was most abundant at sites of tissue remodeling where many apoptotic cells could be

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