C8990

Sp-8-pCPT-cAMPS

≥98% (HPLC), solid

• Synonym(s): 8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic monophosphorothioate, Sp-isomer sodium salt
• Empirical Formula (Hill Notation): C₁₆H₁₄ClN₅O₅PS₂Na
• CAS Number: 129693-13-6
• Molecular Weight: 509.86
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724452
• MDL number: MFCD04113743

Properties

• assay: ≥98% (HPLC)
• form: solid
• packaging: vial of 5 μmol
• solubility: H₂O: >1 mg/mL
• shipped in: dry ice
• storage temp.: −70°C
• SMILES string: [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

Description

General description

Sp-8-pCPT-cAMPS is a nonhydrolyzable analog of cAMP[1] with a p-chlorophenylthio moiety.[2]

Application

Sp-8-pCPT-cAMPS has been used as an agonist for protein kinase A.[3] It has also been used in the inhibition of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) in oligosphere cultures.[2]

Biochem/physiol Actions

Selective cAMP-dependent protein kinase (PKA) activator.

Sp-8-pCPT-cAMPS impairs PIP2 production by phosphatidylinositol 4-phosphate 5-kinase (PIP5K) inhibition.[2] It may be involved in promoting remyelination in astrocytes and neurons. The lipophilicity feature of Sp-8-pCPT-cAMPS aids its cell entry for mediating remyelination.[2] It may play a role in lowering Leishmania proliferation in in vitro studies.[1]

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)